^{Genomics and Molecular Biology}

The living organisms on the earth, from prokaryotes to eukaryotes, have been proliferating for billions of years. To date, they form in more complicated structure, and function in more perfect ways. However, what really determined the complex phenotype, structure and function of living organisms? Where do they store those huge amounts of information? And how do they operate? All of these have been keen questions for people to explore. What has been astonishing, and puzzle is the fact that life is not just a simple group of molecules; instead, it is highly organized. Th ere are connections between nucleus and cytoplasm, a clearly work division between diff erent organizations, and synergy cooperation within organs. Th erefore, a normal living organism is extremely orderly, multi-level, and dynamic. Th e complexity of the organism is not only refl ected in the complexity of the structure of DNA information, but also on the implementation of the information and operation rule. Th is report mainly introduces the rise of noncoding area and great innovation opportunity it off ers, and the role of big data in this fi eld. Meanwhile, this report also introduces what the scientists have explored for the associations between genotype and phenotype. As a result, series of new concepts, such as translational medicine, personalized medicine; precision medicine, etc. have been put forward by medical scientists. All of these

imply that the big changes for medical system, from diagnosis, treatment to health care, are upcoming. It also suggests the birth of a

new generation of huge health care industry.