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Han Xia

Tianjin Medical University General Hospital, China

Biography

Han Xia has his expertise in evaluation and passion in improving the health and wellbeing. In the current study, he showed that lnc-Evf2 is a preosteoblast-enriched lncRNA that is overexpressed in OLF and during osteogenic differentiation, but was down-expressed in OP. Knockdown of lnc-Evf2 significantly inhibits the expression of osteogenic differentiation marker genes and the ALP activity and delays the osteoblastic mineralization process. Mechanistically, we demonstrated that silencing of lnc-Evf2 decreases the protein levels but not the mRNA levels of Notch2, Notch3, and Hes1 in preosteoblasts and mouse embryonic fibroblasts, suggesting that lnc-Evf2 promotes osteogenesis via the Notch signaling. focusing.

Abstract

Abstract : Preosteoblast-enriched lnc-Evf2 facilitates osteogenic differentiation by targeting Notch