Yong Yu
Wellcome Trust Sanger Institute, United Kingdom
Title: Single cell RNA sequencing analysis of bone marrow innate lymphoid progenitors
Biography
Biography: Yong Yu
Abstract
Innate lymphoid cells (ILCs) are a new family of immune cells and play fundamental roles in the development of immune system and protect host from pathogens infection but ILC progenitor development in the bone marrow was not clear. We used single cell RNA sequencing to dissect BM ILC progenitors and identified PD-1 marked a committed ILC progenitor. We further found that activated ILCs in particular ILC2s expressed high levels of PD-1. Indeed, depleting PD-1-high ILC2s substantially reduced type 2 cytokines in immune responses, and inhibited acute lung inflammation induced by papain. Our data therefore demonstrate the value of single cell RNA sequencing in dissecting development and present a new perspective for targeting PD-1 in immunotherapies.
