Tianbo Jin
Xizang Minzu University, China
Title: Genetic polymorphisms of pharmacogenomic VIP variants in seven national minorities from different regions of China
Biography
Biography: Tianbo Jin
Abstract
Pharmacogenomic variant information is well known for major human populations; however, this information is less commonly studied in minorities. We genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Tibetan, Uygur, Miao, Li, Deng, Kyrgyz, Ihoba populations and compared our data with other major eleven populations from the HapMap data set, including ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI and YRI. We also downloaded SNP allele frequencies from the Allele Frequency Database to observe the global genetic variation distribution for these specific loci. Through statistical analysis, we found that genotype frequencies of ADH1B, AHR, CYP3A5, PTGS2, VDR, MTHFR and VKORC1 in our study populations differed widely from those in the 11 HapMap populations. Population structure and F-statistics (Fst) analysis also showed significant differences between these seven minorities and other HapMap populations. Our results complement the information provided by the database of pharmacogenomics on Tibetan, Uygur, Miao, Li, Deng, Kyrgyz, Ihoba populations. We provide a theoretical basis for safer drug administration and individualized treatment plans for these seven populations. We also provide a template for the study of pharmacogenomics in various ethnic minority groups in China.