Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 10th International Conference on Genomics and Molecular Biology Barcelona, Spain.

Day 1 :

OMICS International Genomics 2018 International Conference Keynote Speaker Reiko Kuroda photo
Biography:

Reiko Kuroda obtained her PhD in Chemistry from the University of Tokyo, and carried out her Post-doctoral studies at King’s College London. Her research focuses on chirality, both in the fi eld of Chemistry and Biology: chirality recognition, transfer and amplifi cation in the solid state, development of chiroptical spectroscophotometers to enable condensed-phase measurements, and the molecular basis of snail body handedness. She has published 328 peer-reviewed papers.

Abstract:

Body handedness of gastropod Lymnaea stagnalis is determined by a single gene locus that functions maternally. We have previously shown that the gene dictates the cytoskeletal dynamics at the third cleavage (from the fourth to the eight-cell stage), and only the embryos of dominant chirality exhibit SD (spiral deformation) and SI (spindle inclination) at this stage. Further, we could create fertile snails of mirror-image body plan by altering the chirality of blastomeres through mechanical manipulation at this stage. In this talk, the identifi cation of the handedness-determining gene will be discussed. Using pure dextral (DD) and sinistral (dd) strains as well as its F2 through to F10 backcrossed lines, the single handedness determining-gene locus was mapped by genetic linkage analysis, BAC cloning and chromosome walking. We have identifi ed the actin related diaphanous gene Lsdia1 as the candidate. Th ere are tandemly-repeated highly-homologus genes, Lsdia1 and Lsdia2. Although the cDNA and derived amino acid sequences of the genes are very similar, we could discriminate the two genes/proteins in our molecular biology experiments. Th e Lsdia1 gene of the sinistral strain carries a single point mutation which causes a frameshift mutation abrogating full-length LsDia1 protein expression. In the dextral strain, it is already translated prior to oviposition. Expression of Lsdia1 (only in the dextral strain) and Lsdia2 (in both chirality) decreases aft er the 1-cell stage, with no asymmetric localization throughout.

OMICS International Genomics 2018 International Conference Keynote Speaker Laila Alves Nahum photo
Biography:

Laila Alves Nahum completed her PhD at the University of São Paulo, Brazil and Postdoctoral studies from the Marine Biological Laboratory and Louisiana State University, USA. She is a Researcher at Fiocruz Minas and a Teacher at Promove College of Technology. Her research is focused on the Phylogenomics (Phylogenetics + Genomics) of a broad range of organisms including human pathogens and their vectors. She has published research papers in reputed journals and book chapters.

Abstract:

The availability of genomic data provides an opportunity to understand parasite biology and to identify new drug candidates against neglected diseases aff ecting millions of people worldwide. Functional annotation of genomes, transcriptomes and predicted proteomes is one of the major challenges in sequencing projects. We address this challenge by applying an evolutionary framework to the interpretation of sequence data. Our research projects have been focused on the analyses of distinct protein families in helminths (Schistosoma and others) and protozoans (Leishmania, Trypanosoma, and Plasmodium), which cause a broad range of diseases. Th ese protein families include mainly protein kinases, protein deacetylases, and proteases. Potential homologues in the predicted proteomes of selected taxa are identifi ed by using hidden Markov model profi les. Evolutionary relationships of protein sequences are reconstructed by two character-based methods (Bayesian inference and maximum likelihood). Evolutionary trees are annotated with taxonomic and experimental information based on the scientifi c literature. Our work improves functional annotation of genes and proteins of diverse parasites and their homologues in humans. Furthermore, our work potentially identifi es molecular biomarkers with various applications.

Keynote Forum

Runsheng Chen

Institute of Biophysics - CAS, China

Keynote: Big data in noncoding RNA and precision medicine
OMICS International Genomics 2018 International Conference Keynote Speaker Runsheng Chen photo
Biography:

Runsheng Chen is a Principal Investigator at Institute of Biophysics CAS. He is an academician of the Chinese Academy of Sciences (CAS), and an academician of the International Eurasian Academy of Sciences. He is a member of Human Genome Organization (HUGO), a member of the bio-macromolecule group of Committee on Data for Science and Technology (CODATA), and a member of the bioinformatics professional committee of the International Union of Pure and Applied Physics (IUPAP). He is now the General Secretary and Vice President of Chinese Society of Biophysics, and has published more than 130 papers in SCI.

Abstract:

The living organisms on the earth, from prokaryotes to eukaryotes, have been proliferating for billions of years. To date, they form in more complicated structure, and function in more perfect ways. However, what really determined the complex phenotype, structure and function of living organisms? Where do they store those huge amounts of information? And how do they operate? All of these have been keen questions for people to explore. What has been astonishing, and puzzle is the fact that life is not just a simple group of molecules; instead, it is highly organized. Th ere are connections between nucleus and cytoplasm, a clearly work division between diff erent organizations, and synergy cooperation within organs. Th erefore, a normal living organism is extremely orderly, multi-level, and dynamic. Th e complexity of the organism is not only refl ected in the complexity of the structure of DNA information, but also on the implementation of the information and operation rule. Th is report mainly introduces the rise of noncoding area and great innovation opportunity it off ers, and the role of big data in this fi eld. Meanwhile, this report also introduces what the scientists have explored for the associations between genotype and phenotype. As a result, series of new concepts, such as translational medicine, personalized medicine; precision medicine, etc. have been put forward by medical scientists. All of these
imply that the big changes for medical system, from diagnosis, treatment to health care, are upcoming. It also suggests the birth of a
new generation of huge health care industry.